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Search Results for " oncostatin m receptor "

Targets Recommended: Interleukin

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T76956	Vixarelimab RG-6536,RO-7622888,KPL-716	Interleukin	Immunology/Inflammation
	Vixarelimab (KPL-716) 是一种人源的抗 oncostatin M (OSM)单克隆抗体，对 OSM 受体的β链有亲和力，对 IL-31 和 OSM 的信号传导有抑制作用。Vixarelimab 可用于研究重度结节性痒疹和特发性肺纤维化。
T74734	Truncated ADR58
	Truncated ADR58 通过将全长ADR58的71个碱基缩短至31个碱基而制得。该化合物维持了与全长ADR58相似的功能性，能够高效且选择性地担任人肿瘤抑制素M(OSM)的拮抗剂，阻碍OSM与gp130受体的结合，特异性地抗拒OSM介导的信号传递。Truncated ADR58在研究类风湿性关节炎等相关疾病中有应用。

化合物

Vixarelimab

Cat.No: T76956

Synonym: RG-6536,RO-7622888,KPL-716

Target: Interleukin

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02335	OSMR Protein, Mouse, Recombinant (His) oncostatin M receptor,OSMRB	Mouse	HEK293 Cells
	OSMR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 83.7 kDa and the accession number is O70458-1.
TMPY-01305	OSMR Protein, Human, Recombinant (His) OSMRB,PLCA1,oncostatin M receptor,IL-31RB	Human	HEK293 Cells
	OSMR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.6 kDa and the accession number is Q99650-1.
TMPJ-01467	Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His) Oncostatin-M,OSM	Human	E. coli
	Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, which Inhibits the proliferation of a number of tumor cell lines. It stimulates proliferation of AIDS-KS cells. OSM regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is considered as a pleiotropic cytokine that initiates its biological ac...
TMPH-03345	Oncostatin M/OSM Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Oncostatin M/OSM Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 24.2 kDa and ...
TMPK-01114	IL-31RA Protein, Human, Recombinant (aa 20-519, His) GLM-RMGC125346,CRL3,GLM-R,PRO21384,Gp130-like receptor	Human	HEK293 Cells
	Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons....
TMPJ-00047	IL-31 Protein, Human, Recombinant IL-31,Interleukin-31,白介素,白细胞介素,IL31	Human	E. coli
	Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper...
TMPK-01113	IL-31RA Protein, Human, Recombinant (aa 20-519, hFc) PRO21384,GLM-RMGC125346,GLM-R,IL-31R-alpha,IL-31RA,ZcytoR17,...	Human	HEK293 Cells
	Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons....
TMPK-00646	gp130/IL6ST Protein, Rhesus macaque, Recombinant (His) IL-6 R β,gp130,IL6ST,IL-6R-beta,CD130,gp130/CD130/IL-6 R β,C...	Rhesus	HEK293 Cells
	gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1. These cytokines exhibit pleiotropic biological activities in, for instance, immune, hematopoietic, and neural systems, and function in a redundant manner owing to the shared usage of gp130. gp130/IL6ST Protein, Rhesus macaque, Recombinant (His) is expre...
TMPK-00412	gp130/IL6ST Protein, Human, Recombinant (His) gp130,CD130,IL-6 R beta,IL6ST,IL-6R-β,IL-6R-beta,IL-6RB,gp13...	Human	HEK293 Cells
	gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1. These cytokines exhibit pleiotropic biological activities in, for instance, immune, hematopoietic, and neural systems, and function in a redundant manner owing to the shared usage of gp130. gp130/IL6ST Protein, Human, Recombinant (His) is expressed in H...
TMPK-01096	IL-31RA Protein, Mouse, Recombinant (His) GPL,CRL3Glmr,IL-31RA,GLM-R,ZcytoR17,CRL3,PRO21384,GLM-RMGC12...	Mouse	HEK293 Cells
	Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons....